Magic Mushrooms – The Most Popular Substances for Microdosing

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Magic mushrooms, or hallucinogens, are one of the most popular substances for microdosing. They are safe, natural and tend to produce pleasant and productive effects.

Psilocybin, the active ingredient in mushrooms, works by activating the serotonin 5-HT2A receptors in the brain. These receptors are found throughout the brain, and are especially dense in the cerebral cortex, especially in the prefrontal, parietal, and somatosensory lobes. The molecules of psilocybin and other psychedelic tryptamines are shaped like serotonin. This similarity allows them to bind to serotonin receptors (unlike SSRIs and amphetamines, which work by increasing the amount of serotonin in the brain). Mushrooms also contain psilocin and beocystin, secondary tryptamines that produce psilocybin-like effects.

Activation of 5-HT2A receptors causes a cascade of effects in the brain. For one thing, it appears to be the cause of neurons producing more brain-derived neurotrophic factor, or BDNF, which makes neurons grow and connect more easily. It also causes the brain to release more glutamate, which in turn has numerous after-effects. One of them is the release of dopamine in the prefrontal cortex, which helps you focus.

In general, psilocybin makes the brain more awake. In an fMRI, the crust glows like a lightbulb, and there appears to be more activity on its surface. At the same time, normal brain activity is disrupted, and the default neural network (the part of the brain that is most active during wakefulness) is less active than usual. The parts of the brain that never communicate, "talk" to each other, showing that the brain is changing and experiencing things beyond normal.

With microdosing, these effects are mitigated, but they are still present.

Benefits Of Microdosing with Psilocybin

People who microdose with psilocybin tend to have more energy, an easier time connecting thoughts to emotions, and are more likely to see patterns and experience "leaps" of understanding. Many consumers report feeling more motivated to exercise, start creative projects, and solve difficult problems. For those who find microdosing LSD too stimulating, the effect of mushrooms is more moderate in comparison.

Microdosing with mushrooms typically lasts 4-6 hours, much less than a microdosing of acid. This shorter experience allows more control of the duration and helps to time the dose so that it does not interfere with sleep.

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